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ForwardGalectin-3: A Promising Target in the Fight Against Alzheimer's Disease
Alzheimer’s Disease is a progressive brain disorder that gradually impairs memory and cognitive functions essential for daily living. As the leading cause of dementia, it is characterized by the accumulation of amyloid beta (Abeta) proteins, which form toxic plaques in the brain. These plaques disrupt communication between neurons, resulting in cognitive deficits. In addition to Abeta plaques, another protein called Galectin-3 (Gal3) is found in abnormally high levels in the brains of Alzheimer's patients. Gal3 binds to Abeta, facilitating the formation of toxic plaques by acting as a glue. These plaques then deposit on neurons, obstructing communication signals and leading to cognitive symptoms associated with dementia and Alzheimer’s Disease. Recent research has focused on targeting Gal3 to prevent it from promoting plaque formation. By inhibiting Gal3, the formation of toxic Abeta plaques can be reduced or dissolved, thereby restoring neuron communication and improving cognitive function. The therapeutic potential of targeting Gal3 has been demonstrated in pre-clinical studies using Alzheimer’s disease animal models. These studies have shown significant reductions in total Abeta plaques and other neurodegeneration biomarkers after short-term treatment, supporting the efficacy of this approach in mitigating the effects of Alzheimer's Disease.
Target Audience
This activity is intended to meet the educational needs of the healthcare team including but not limited to:
- Physicians
- Residents
- Medical Students
- Pharmacists
- Physician assistants
- Nurses
- Other Healthcare Professionals
Learning Objectives
After participating in this activity, learners will be able to:
- Equip HCPs with practical knowledge on how to integrate Gal3-related diagnostic and therapeutic strategies into clinical practice.
- Discuss current research and emerging therapies targeting Gal3, including preclinical and clinical studies.
Disclosure of Relevant Financial Relationships
In accordance with The Standards for Integrity and Independence, GW requires all planners, faculty, and others in control of educational content to disclose the absence or existence of all financial relationships (of any dollar amount) with any ineligible companies within the past 24 months. We define ineligible companies as those whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on patients.
GW reviews all disclosure statements to determine which financial relationships are relevant to the educational content of the CE Activity. An individual is considered to have a relevant financial relationship if the educational content an individual can control is related to the business lines or products of the ineligible company.
Disclosure Statement(s)
Absence of Relevant Financial Relationships
None of the planners, faculty, or others in a position to control content for this educational activity have relevant financial relationship(s) to disclose with ineligible companies whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on patients.
Disclaimer
The information in this educational activity is provided for general medical education purposes only and is not meant to substitute for the independent medical judgment of a physician relative to diagnostic and treatment options of a specific patient’s medical condition. The viewpoints expressed in this CME activity are those of the authors/faculty. They do not represent an endorsement by The George Washington University.
Accreditation Statements
The George Washington University School of Medicine and Health Sciences is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.
Credit Designation Statement(s)
Physicians (CME)
This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of The George Washington University School of Medicine and Health Sciences and The American Academy of Anti-Aging Medicine. The George Washington University School of Medicine and Health Sciences is accredited by the ACCME to provide continuing medical education for physicians.
The George Washington University School of Medicine and Health Sciences designates this enduring activity for a maximum of 1.00 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
American Osteopathic Association (AOA)
The George Washington University School of Medicine and Health Sciences is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.
The American Osteopathic Association (AOA) recognizes AMA PRA Category 1 Credit™ earned as AOA Category 2 credit.
It is the physician's responsibility to report CME credits earned directly to AOA.
Ways to report CME Credit:
- Email: Your CME Certificate to Physician Education & CME at [email protected].
- Online: Via the CME Self-Reporting Tool (login required).
Other Healthcare Professionals (Attendance)
All other healthcare professionals who successfully complete the activity will receive a Certificate of Attendance. Many credentialing bodies such as the ANCC, AANP, and AAPA accept certificates of attendance for educational activities certified for AMA PRA Category 1 Credit(s)™ from organizations accredited by the ACCME. If you have doubts about whether an activity will qualify for CE, please contact your certifying organization for clarification on credit eligibility.
Available Credit
- 1.00 AMA PRA Category 1 Credit™The George Washington University School of Medicine and Health Sciences is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.
- 1.00 Completion
Registration Instructions
Please note that you must be logged in to complete the CE credit claim process.
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