Title: Chronic Pain and Its Comorbidities: The Importance of Sex when Investigating Mechanisms and Therapies

Speaker: John Bethea, PhD

Format: In-person

Learning Objectives:

  • Explain the role of TNFR2 signaling in chronic pain pathophysiology and recovery, including its anti-inflammatory, neuroprotective, and tissue-reparative effects across neuropathic pain and osteoarthritis models. 
  • Describe sex-specific differences in the mechanisms and outcomes of chronic pain and its comorbidities, including differential responses in opioid and cannabinoid pathways, as well as the development of heart failure and cognitive decline. 
  • Evaluate emerging therapeutic strategies targeting TNFR2 signaling, including their potential to treat chronic pain and modify associated conditions such as osteoarthritis-induced heart failure and neurodegenerative disease progression. 
Session date: 
04/09/2026 - 12:00pm to 1:00pm EDT
Add to calendar: 
  • 1.00 ABIM MOC 2
  • 1.00 AMA PRA Category 1 Credit™
    The George Washington University School of Medicine and Health Sciences is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.
  • 1.00 Completion
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